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Antipsychotics Do Not Provide a Clinically Meaningful Benefit Over the Short-Term: A Review of the Evidence

Mad in America

No Trials in Medication-Naïve Patients When the first antipsychotic, chlorpromazine, was introduced into asylum medicine in 1954, there was no FDA requirement that the manufacturer of a drug had to conduct randomized clinical trials to prove its efficacy.

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Centanafadine Study: New ADHD Drug Effective for Adults and Kids

ADDitude

June 24, 2025 Centanafadine — a norepinephrine, dopamine, and serotonin reuptake inhibitor (NDSRI) — is effective at treating ADHD in adults, adolescents, and children, according to Phase 3 trials sponsored by the drug’s manufacturer, Otsuka Pharmaceuticals. Centanafadine had a significant impact on ADHD symptoms,” explained Tim Wilens, M.D.,

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The Editorial Demise of Psychotherapy and Psychosomatics Is Bad News For Us All

Mad in America

Studies of patients hospitalized for depression in the first half of the 20 th century, both in the U.S. It is indeed rare to see such issues debated: is this because of some censorship operated by medical journals, meeting organizers, and certain pharmaceutical manufacturers?

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Do Critics of Biological Psychiatry Have an Alternative to a Life of “Whack-A-Mole”?

Mad in America

Establishment psychiatry has shown this same unscientific thinking in its manufacturing of other biological theories of mental illness. So, I am aware of no critic of establishment psychiatry who is anti-drug and who does not acknowledge the possible short-term benefit of a tranquilizing drug in preventing hospital or prison incarceration.

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Psychiatry Criticism Politics: When the Enemy of Your Enemy Is Not Your Friend

Mad in America

I dislike it for classifying human reactions that create tension—especially for authorities—as defective in some biological way, and for then exploiting this manufactured defectiveness by prescribing drugs and other remedies that routinely have serious adverse effects; and I dislike it for its financial partnering with drug companies.

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Akathisia After a Five-Year Taper: Chained to an Antidepressant Forever

Mad in America

I n my article, What I learned as a Moderator for an Antidepressant Taper Support Group, I described working alongside psychiatrists as a licensed clinical social worker in a psychiatric hospital for 18 years and never hearing one word about withdrawal. Then I tried to go off Cymbalta and all hell broke loose.

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The American Journal of Psychiatry’s Answer to MIA: A Silence that Speaks Volumes

Mad in America

The Citizens Commission on Human Rights, a group associated with Scientology, then issued a press release urging Congress to ban this “killer drug,” and that’s when Eli Lilly, manufacturer of Prozac, conjured up a media strategy to save its drug that has proven effective ever since.