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Antidepressants are Americas first-line treatment for the most common mentalhealth problems, e.g., depression, anxiety, and insomnia. Edmund Pigott and colleagues published an omnibus 2023 re-analysis of STAR*D patient-level data, attempting to correct the scientific record. That is not so.
The prevailing logic goes: if we can validate biometric tests that are clinically predictive of mentalhealth concerns like in other medical fields, we can more precisely, effectively, and without (solely) subjective clinical observation, treat the malady. Should we give up the search for biomarkers altogether?
In summary, researchers have found no serotonin nor any other neurotransmitter association with depression, no neurobiological associations, and no genetic associations. The cover of the December 2023 Psychiatric Times issue announced : “STAR*D Dethroned? But What If It’s Broken?” The answer is overwhelming life pains.
April 23, 2025 Serotonin neurons signal to the brain the expected value of near-future rewards, a discovery that helps to clarify the neurotransmitter’s complex role in regulating mood, learning, and more, according to a new study in Nature. bioRxiv (2023).11.12.566727;
As such, the scandal now serves as a historical verdict on the ethics of American psychiatry, and by extension, the National Institute of MentalHealth (NIMH). The Media Remain Silent In September of 2023, MIA published a long report titled The STAR*D Scandal: Scientific Misconduct on a Grand Scale.
Depression commonly refers to a mentalhealth disorder characterized by persistent feelings of sadness, hopelessness, and a loss of interest in activities that you once enjoyed. If you’re struggling with alcohol addiction and depression, call us today and start healing in the Los Angeles, California area.
It does this by enhancing GABA_A receptors (inhibitory neurotransmitter) and inhibiting NMDA glutamate receptors (excitatory neurotransmitter). Epidemiology & Pathogenesis 4 , 5 Genetics , environmental influences , and mentalhealth comorbidities contribute to vulnerability. stupor, or coma in severe cases).
2 Or you are told you have a lack of insight into your disease, which is a symptom of your mental illness, a catch-22 situation from which there is no escape. In 2014, the Danish Ministry of Health issued a licence to kill. Joseph Biederman was an example of grandiosity. My Critical Psychiatry Textbook is freely available.
I didn’t know Wallace was a poster boy for antidepressant withdrawal because I didn’t know that antidepressant withdrawal was common, or that I would be experiencing it myself and understanding firsthand the hellish bodily and mental feelings that make one long for death, for everything to stop. Down from 40mg.
It plays a key role in modulating neurotransmitters, increasing dopamine and serotonin, which leads to elevated mood and focus. Similar results were found in a 2024 systematic review of 55 studies investigating the role of pubertal hormones on mentalhealth conditions. J Health Soc Behav. J Adolesc Health.
Would you tell us a little bit about what it was like for you in the mentalhealth system before you went into withdrawal? I embraced mentalhealth support for many years because I found that it made me healthier. When I did manage to taper off a bit, I felt an immediate improvement in my health.
In their analysis the independent variable was SSRI use and they examined biological sex, mentalhealth problems, intensity of romantic love, obsessive thinking, commitment, and frequency of sex as the dependent variables. Serotonin is a very important neurotransmitter in the human brain. 2023 Nov 10;13(11):921.
Joanna Moncrieff, Chemically Imbalanced (2025) E stablishment psychiatry has recently switched the biological cause of mental illness from a chemical imbalance to a brain circuitry defect. Establishment psychiatry has shown this same unscientific thinking in its manufacturing of other biological theories of mental illness.
The young dancer’s story—at her request and her father’s, she’ll remain anonymous—illustrates both the lure and harms of social media, which has been drawing more and more attention of late for its ubiquity, its addictiveness, its corporate habits, and its role in the youth mentalhealth crisis. hours a day on social media.”
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