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Antipsychotics Do Not Provide a Clinically Meaningful Benefit Over the Short-Term: A Review of the Evidence

Mad in America

No Trials in Medication-Naïve Patients When the first antipsychotic, chlorpromazine, was introduced into asylum medicine in 1954, there was no FDA requirement that the manufacturer of a drug had to conduct randomized clinical trials to prove its efficacy.

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NRx Pharmaceuticals Applies for FDA National Priority Voucher for Intravenous Ketamine (NRX-100)

Psychiatric Times

2 In a press release, NRx Pharmaceuticals said NRX-100 is well positioned for this designation, citing its alignment with national health priorities such as addressing the mental health crisis, innovating treatment for unmet needs, and enhancing domestic drug manufacturing. 1 NRx appears to be committed to the mental health space.

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In Brain Chemistry We Trust—The Gospel According to Pharma

Mad in America

What began as a wonderful career combining my scientific knowledge with creative writing gradually revealed itself as something far more troubling: I was helping to manufacture “facts” about diseases and treatments that would shape medical practice for decades.

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FDA Requires New Label Warning of Weight Loss Risk in Pediatric Patients Taking Extended-Release Stimulants for ADHD

Psychiatric Times

Manufacturers of extended-release stimulants that currently do not have a Limitation of Use section in the labeling will be required to add one about this risk, and manufacturers that do already have a Limitation of Use section will be required to revise the labeling to ensure consistent messaging.

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False Information in UK Package Inserts for Antidepressants About a Chemical Imbalance

Mad in America

I looked up a PIL this month for citalopram from one manufacturer , and the text was These medicines help to correct certain chemical imbalances in the brain that are causing the symptoms of your illness. ” Two months later, the MHRA responded.

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Centanafadine Study: New ADHD Drug Effective for Adults and Kids

ADDitude

June 24, 2025 Centanafadine — a norepinephrine, dopamine, and serotonin reuptake inhibitor (NDSRI) — is effective at treating ADHD in adults, adolescents, and children, according to Phase 3 trials sponsored by the drug’s manufacturer, Otsuka Pharmaceuticals.

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Senators Propose Ban on Drug Advertising to Consumers

Mad in America

Maine) introduced a bill Thursday that would ban pharmaceutical manufacturers from using direct-to-consumer advertising, including social media, to promote their products. From The Wall Street Journal : “Sens. Bernie Sanders (I., and Angus King (I.,